| Property | Description |
|---|---|
| Systematic Name | 26-amino-3,6,9,12,15,18,21,24-octaoxahexacosanol / Amino-nonaethylene glycol-hydroxyl |
| CAS Number | 15332-95-3 |
| Molecular Formula | C₁₈H₃₉NO₉ |
| Molecular Weight | ~ 413.5 g/mol |
| Structural Feature | One end is a primary amino group (-NH₂), the other is a hydroxyl group (-OH), linked by a PEG chain composed of nine ethylene glycol units (-OCH₂CH₂-). |
| Purity & Specifications | Typically ≥95% or ≥98%, available in packaging ranging from 1mg to 10g. |
| Physical Properties | Usually a white solid or powder at room temperature. Highly soluble in water and common organic solvents (e.g., DMSO, dichloromethane). |
| Storage Conditions | Requires sealed, light-protected, and low-temperature storage. Recommended storage at -20°C or 4°C. |
Key Characteristic: Monodispersity
A primary advantage of H₂N-PEG₉-OH is that it is typically a monodisperse PEG derivative. This is a crucial concept:
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Precision and Uniformity: It means all molecules in the product have a completely identical and precisely defined PEG chain length, consisting of exactly 9 ethylene glycol units with an absolutely uniform molecular weight.
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Significance: Compared to traditional polydisperse PEG with varying chain lengths, monodisperse PEG ensures precise and reproducible experimental results in research and drug development. It allows for the quantitative study of how PEG chain length affects drug behavior (e.g., half-life, efficacy).
Primary Applications
Leveraging its bifunctionality and defined chain length, H₂N-PEG₉-OH is extensively used in the following fields:
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Bioconjugation and Drug Development
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Function: The amino group (-NH₂) can readily react with groups like carboxyl groups (-COOH) on proteins, peptides, or drug molecules to form stable linkages.
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Uses: Employed for drug modification (e.g., prolonging circulation time), preparation of biosensors, and biomolecule labeling (e.g., attaching fluorescent dyes).
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Material Surface Modification
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Function: Used to modify surfaces such as nanoparticles or biochips.
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Uses: Introduces a hydrophilic PEG layer to improve biocompatibility, reduce non-specific adsorption, and provide reactive sites for subsequent conjugations.
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