DSPE-PEG-OH (Distearoyl Phosphatidylethanolamine-Polyethylene Glycol-Hydroxyl)is an amphiphilic block copolymer composed of a hydrophobic DSPE moiety, a hydrophilic PEG chain, and a terminal hydroxyl functional group. Its molecular structure endows it with self-assembly properties, enabling the formation of nanocarriers such as micelles or liposomes in aqueous media.

I. Structural Features

• DSPE moiety: Composed of two C18 long-chain fatty acids, it is strongly hydrophobic and can embed into liposomes or biological membranes, providing structural stability.

• PEG chain: Highly hydrophilic, imparting water solubility, flexibility, and biocompatibility to the molecule, while extending in vivo circulation time.

• Hydroxyl terminal: Chemically inert, serving as an active site for further functionalization, such as conjugation with drugs, fluorescent probes, etc.

II. Applications

• Targeted drug delivery: Used to load chemotherapeutic agents (e.g., doxorubicin), siRNA, or gene vectors, enabling precision tumor delivery through conjugation with targeting ligands.

• Bioimaging: Conjugated with fluorescent dyes (e.g., Cy5.5) or radionuclides for tumor imaging and therapeutic efficacy monitoring.

• Functionalization of nanomaterials: Modified onto the surface of gold nanoparticles, quantum dots, etc., to enhance biocompatibility and signal detection capabilities.

III. Handling and Storage

• Storage requirements: Protect from light and store at –20°C to avoid oxidation or hydrolysis.

• Safety precautions: Wear gloves and goggles during handling; dispose of waste in accordance with biosafety regulations.

This material holds broad application prospects in the fields of biomedicine and nanotechnology.