Nom : chaîne latérale du sémaglutide ; Modificateur d'ester actif de sémaglutide ; Ester activé par NHS à chaîne latérale de sémaglutide
Abréviation du produit : tBuO-Ste-Glu (AEEA-AEEA-OSu) -OtBu
N° CAS : 1118767-15-9
Code produit : 06040003000
Stockage : -20±5°C
La chaîne latérale du sémaglutide (tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu) est un groupe protecteur crucial pour les chaînes latérales dans la synthèse peptidique. Il présente une excellente solubilité et stabilité, protégeant efficacement les chaînes latérales des acides aminés contre les modifications ou la dégradation non spécifiques lors des réactions chimiques. Largement utilisée dans la synthèse peptidique en phase solide et dans les modifications ultérieures des groupes fonctionnels, la chaîne latérale du sémaglutide aide à contrôler les conditions et la sélectivité de la réaction, en minimisant les réactions secondaires pour améliorer la pureté et le rendement du produit.
I. Candidatures
Drug Modification: tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu is utilized in modifying small molecule drugs, proteins, antibodies, and other bioactive molecules. By forming stable amide bonds, it enhances drug solubility, stability, or targeting specificity, thereby improving therapeutic efficacy and safety. Particularly significant in the development of long-acting peptide drugs like Semaglutide, it plays a critical role in optimizing pharmacokinetic properties and therapeutic effects.
Targeted Drug Delivery: Leveraging its high reactivity and biocompatibility, tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu is employed in constructing targeted drug delivery systems. This facilitates precise drug release within specific tissues or cells, enhancing therapeutic efficacy while reducing side effects.
Biological Probes and Diagnostic Reagents: As a component of biological probes or diagnostic reagents, this compound can detect specific molecules or cellular activities within organisms, providing robust support for disease diagnosis and treatment.
II. Production and Storage
Production: The production of tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu is typically carried out by specialized pharmaceutical intermediate manufacturers equipped with advanced synthesis technologies and stringent quality control systems.
Storage: It is recommended to store tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu at -20°C to ensure stability and activity.
III. Supplier Information
Currently, multiple suppliers, including but not limited to Xiamen Sinobestech Biotechnology Co., Ltd., offer tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu. These suppliers possess extensive production experience and rigorous quality control processes, ensuring high-quality products and excellent service for customers.
Related Recommendations:
Name | Abbreviation | CAS# |
---|---|---|
Somarutopeptide carboxylic acid modifier | tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu | 1118767-16-0 |
Somarutopeptide active ester modifier | tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu | 1118767-15-9 |
Somarutopeptide deprotection active ester modifier | HO-Ste-Glu(AEEA-AEEA-OSu)-OH | 1169630-40-3 |
Somarutopeptide deprotection active ester modifier | HO-Ste-Glu(AEEA-AEEA-OSu)-OH(苄基路线) | 1169630-40-3 |
Somarutopeptide side chain analogue 2 | tBuO-Ste-Glu(AEEEA-AEEEA-OH)-OtBu | / |
Somarutopeptide side chain analogue 3 | tBuO-Ste-AEEEA-AEEEEEEA-OH | / |
Somarutopeptide side chain analogue 4 | tBuO-Bz-Seb-Glu(AEEA-AEEA-OH)-OtBu | / |
Somarutopeptide sodium salt modifier | tBuO-Ste-Glu(AEEA-AEEA-ONa)-OtBu | / |
Somarutopeptide side chain analogue 6 | HO-Ste-Glu(AEEA-AEEA-Mal)-OH | / |
Somarutopeptide side chain analogue 7 | HO-Ara-Glu(AEEA-AEEA-Mal)-OH | / |
/ | HO-Ara-Glu(NH-PEG6-NH-Mal)-OH | / |
/ | HO-Ara-NH-PEG9-NH-Mal | / |
Somarutopeptide propionaldehyde modified side chain | tBuO-Ste-Glu(AEEA-AEEA-NH-pALD)-OtBu | / |
Fmoc-Lys Somarutopeptide side chain | Fmoc-Lys(tBuO-Ste-Glu(AEEA-AEEA)-OtBu)-OH | 1662688-20-1 |
Somarutopeptide side chain analogue 14 | Fmoc-Lys(tBuO-Pal-Glu(AEEA-AEEA)-OtBu)-OH | / |
Somarutopeptide side chain analogue 15 | Fmoc-Lys(Pal-Glu(AEEA-AEEA)-OtBu)-OH | / |
/ | Fmoc-Lys(tBuO-Ara-Glu(AEEA)-OtBu)-OH | / |